Loading...
Chemical structure of JH-VIII-157-02

GC33062

JH-VIII-157-02

Also known as 2-[4-(3-cyano-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)pyrazol-1-yl]-N,N-dimethylacetamide

JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells

ChemicalCAS1639422-97-1MW465.55FormulaC28H27N5O2
CAS number
1639422-97-1
Molecular weight
465.55
Formula
C28H27N5O2
Solubility
DMSO ： ≥ 25 mg/mL (53·70 mM)
InChIKey
IDGNCVHQDDOPND-UHFFFAOYSA-N
Catalogue number
GC33062
Brand
GLPBIO
Computed properties PubChem CID 127037084 · XLogP 4.5 · TPSA 94.8 Ų · H-bond donors 1
XLogP
4.5
TPSA
94.8 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
35

SMILES CCC1=CC2=C(C=C1C3=CN(N=C3)CC(=O)N(C)C)C(C4=C(C2=O)C5=C(N4)C=C(C=C5)C#N)(C)C

Computed descriptors from PubChem (CID 127037084), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.