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Chemical structure of JH-XVI-178

GC65577

JH-XVI-178

Also known as 8-[3-chloro-5-(1-methylindazol-5-yl)-2H-pyrazolo[3,4-b]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one

JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties

ChemicalCAS2648453-53-4MW435.91FormulaC22H22ClN7O
CAS number
2648453-53-4
Molecular weight
435.91
Formula
C22H22ClN7O
InChIKey
YLJSAFSDGFNKAC-UHFFFAOYSA-N
Catalogue number
GC65577
Brand
GLPBIO
Computed properties PubChem CID 156445498 · XLogP 2.9 · TPSA 91.7 Ų · H-bond donors 2
XLogP
2.9
TPSA
91.7 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
2
Heavy atoms
31

SMILES CN1C2=C(C=C(C=C2)C3=C(C4=C(NN=C4N=C3)Cl)N5CCC6(CCNC6=O)CC5)C=N1

Computed descriptors from PubChem (CID 156445498), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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