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Chemical structure of JH-II-127

GC19205

JH-II-127

Also known as [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6·6 nM, 2·2 nM ,47·7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T

ChemicalCAS1700693-08-8MW416.86FormulaC19H21ClN6O3
CAS number
1700693-08-8
Molecular weight
416.86
Formula
C19H21ClN6O3
Solubility
DMSO ： ≥ 30 mg/mL (71·97 mM)
InChIKey
HUEKBQXFNHWTQQ-UHFFFAOYSA-N
Catalogue number
GC19205
Brand
GLPBIO
Computed properties PubChem CID 112499966 · XLogP 2.5 · TPSA 104 Ų · H-bond donors 3
XLogP
2.5
TPSA
104 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
29

SMILES CNC1=NC(=NC2=C1C(=CN2)Cl)NC3=C(C=C(C=C3)C(=O)N4CCOCC4)OC

Computed descriptors from PubChem (CID 112499966), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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