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Chemical structure of JH-XI-10-02

GC65471

JH-XI-10-02

Also known as 3-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-N-[(3S,5S,8R,9S,10S,13S,14S,17S)-17-isoquinolin-7-yl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]-N-methylpropanamide

JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK· JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM· JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels· JH-XI-10-02 shows no effect on CDK19

ChemicalCAS2209085-22-1MW920.14FormulaC53H69N5O9
CAS number
2209085-22-1
Molecular weight
920.14
Formula
C53H69N5O9
Solubility
DMSO ： 100 mg/mL (108·68 mM; Need ultrasonic)
InChIKey
JECHBTRAPARMGI-GFTKVEOVSA-N
Catalogue number
GC65471
Brand
GLPBIO
Computed properties PubChem CID 145708490 · XLogP 7.2 · TPSA 166 Ų · H-bond donors 2
XLogP
7.2
TPSA
166 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
19
Heavy atoms
67

SMILES C[C@]12CC[C@@H](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C5=CC6=C(C=C5)C=CN=C6)C)N(C)C(=O)CCOCCOCCOCCOCCNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O

Computed descriptors from PubChem (CID 145708490), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.