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Chemical structure of EGFR/HER2-IN-9

GC73415

EGFR/HER2-IN-9

Also known as (E)-4-[(4aR,7aS)-2,3,4a,5,7,7a-hexahydro-[1,4]dioxino[2,3-c]pyrrol-6-yl]-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]but-2-enamide

EGFR/HER2-IN-9 (Compound 1) is an EGFR and HER2 inhibitor with IC50s of 3·2, 8·3 and 14 nM against EGFR, EGFR T790M and HER2, respectively

ChemicalCAS1637253-79-2MW513.95FormulaC25H25ClFN5O4
CAS number
1637253-79-2
Molecular weight
513.95
Formula
C25H25ClFN5O4
Solubility
DMSO ： 100 mg/mL (194·57 mM; Need ultrasonic)
InChIKey
REGOTSLWVKSZRG-GYQWKJCYSA-N
Catalogue number
GC73415
Brand
GLPBIO
Computed properties PubChem CID 117685125 · XLogP 3 · TPSA 97.8 Ų · H-bond donors 2
XLogP
3
TPSA
97.8 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
36

SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4C[C@@H]5[C@H](C4)OCCO5

Computed descriptors from PubChem (CID 117685125), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.