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Chemical structure of EGFR-IN-7

GC35966

EGFR-IN-7

Also known as 5-bromo-4-N-(5-dimethylphosphorylquinoxalin-6-yl)-2-N-[2-methoxy-5-methyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine

EGFR-IN-7 is a potent, selective and orally active EGFR kinase inhibitor· EGFR-IN-7 has inhibitory effect for for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) with IC50 values of 7·92 nM and 0·218 nM, respectively· EGFR-IN-7 shows anti-tumor activity· EGFR-IN-7 can be used for the research of various cancers

ChemicalCAS2267329-76-8MW694.6FormulaC32H41BrN9O2P
CAS number
2267329-76-8
Molecular weight
694.6
Formula
C32H41BrN9O2P
Solubility
DMSO： 5 mg/mL (7·20 mM; ultrasonic and warming and adjust pH to 5 with 0·1 M HCL and heat to 60°C)
InChIKey
ZYSKXRAGBGLELB-UHFFFAOYSA-N
Catalogue number
GC35966
Brand
GLPBIO
Computed properties PubChem CID 138911391 · XLogP 4.4 · TPSA 112 Ų · H-bond donors 2
XLogP
4.4
TPSA
112 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
8
Heavy atoms
45

SMILES CC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)C)OC)NC4=NC=C(C(=N4)NC5=C(C6=NC=CN=C6C=C5)P(=O)(C)C)Br

Computed descriptors from PubChem (CID 138911391), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.