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Chemical structure of EGFR-IN-3

GC19132

EGFR-IN-3

Also known as N-[3-[2-[2,3-difluoro-4-[4-(2-hydroxyethyl)piperazin-1-yl]anilino]quinazolin-8-yl]phenyl]prop-2-enamide

EGFR-IN-3 is a third-generation EGFR TKI, with GI50 values of 5 nM (EGFR L858R/T790M), 10 nM (EGFR del19) and 689 nM (EGFR WT), respectively· EGFR-IN-3 has the potential for NSCLC research

ChemicalCAS1660963-42-7MW530.57FormulaC29H28F2N6O2
CAS number
1660963-42-7
Molecular weight
530.57
Formula
C29H28F2N6O2
Solubility
DMSO ： 125 mg/mL (235·60 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
IDRGFNPZDVBSSE-UHFFFAOYSA-N
Catalogue number
GC19132
Brand
GLPBIO
Computed properties PubChem CID 117909640 · XLogP 4.3 · TPSA 93.6 Ų · H-bond donors 3
XLogP
4.3
TPSA
93.6 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
39

SMILES C=CC(=O)NC1=CC=CC(=C1)C2=CC=CC3=CN=C(N=C32)NC4=C(C(=C(C=C4)N5CCN(CC5)CCO)F)F

Computed descriptors from PubChem (CID 117909640), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.