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Chemical structure of EGFR-IN-11

GC62562

EGFR-IN-11

Also known as 9-[(3R)-1-cyclopropylsulfonylpyrrolidin-3-yl]-2-N-[4-(4-methylpiperazin-1-yl)phenyl]-8-N-phenylpurine-2,8-diamine

EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18 nM for triple mutant EGFRL858R/T790M/C797S· EGFR-IN-11 significantly suppresses the EGFR phosphorylation, induce the apoptosis, and arrest cell cycle at G0/G1

ChemicalCAS2463200-44-2MW573.71FormulaC29H35N9O2S
CAS number
2463200-44-2
Molecular weight
573.71
Formula
C29H35N9O2S
Solubility
DMSO ： 125 mg/mL (217·88 mM; Need ultrasonic)
InChIKey
RNEHWYIFHKBZAW-XMMPIXPASA-N
Catalogue number
GC62562
Brand
GLPBIO
Computed properties PubChem CID 145712397 · XLogP 3.7 · TPSA 120 Ų · H-bond donors 2
XLogP
3.7
TPSA
120 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
8
Heavy atoms
41

SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C(=N3)N(C(=N4)NC5=CC=CC=C5)[C@@H]6CCN(C6)S(=O)(=O)C7CC7

Computed descriptors from PubChem (CID 145712397), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.