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Chemical structure of PF-06733804

GC70341

PF-06733804

Also known as 6-amino-5-[(3S)-4,4-difluoro-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]pyrrolidin-3-yl]oxy-N-methylpyridine-3-carboxamide

PF-06733804 is a potent pan-Trk inhibitor in cell-based assays withIC50s of 8·4 nM, 6·2 nM and 2·2 nM for TrkA, TrkB and TrkC, respectively

ChemicalCAS1873373-33-1MW474.38FormulaC20H19F5N4O4
CAS number
1873373-33-1
Molecular weight
474.38
Formula
C20H19F5N4O4
InChIKey
FTAFQADCGCSJAH-HNNXBMFYSA-N
Catalogue number
GC70341
Brand
GLPBIO
Computed properties PubChem CID 118868365 · XLogP 2.5 · TPSA 107 Ų · H-bond donors 2
XLogP
2.5
TPSA
107 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
6
Heavy atoms
33

SMILES CNC(=O)C1=CC(=C(N=C1)N)O[C@H]2CN(CC2(F)F)C(=O)CC3=CC=C(C=C3)OC(F)(F)F

Computed descriptors from PubChem (CID 118868365), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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