GC32977
PF-06726304
Also known as 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
PF-06726304 is a potent and selective EZH2 inhibitor· PF-06726304 inhibits wild-type and Y641N mutant EZH2 with Kis of 0·7 and 3·0 nM, respectively· PF-06726304 displays robust antitumor growth activity
ChemicalCAS1616287-82-1MW446.33FormulaC22H21Cl2N3O3
- CAS number
- 1616287-82-1
- Molecular weight
- 446.33
- Formula
- C22H21Cl2N3O3
- Solubility
- DMSO ： ≥ 15 mg/mL (33·61 mM)
- InChIKey
- PDKDOPJQPKXNCT-UHFFFAOYSA-N
- Catalogue number
- GC32977
- Brand
- GLPBIO
Computed properties PubChem CID 86723730 · XLogP 3.6 · TPSA 75.4 Ų · H-bond donors 1
- XLogP
- 3.6
- TPSA
- 75.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 30
SMILES CC1=CC(=C(C(=O)N1)CN2CCC3=C(C=C(C(=C3C2=O)Cl)C4=C(ON=C4C)C)Cl)C
Computed descriptors from PubChem (CID 86723730), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il