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Chemical structure of PF-06737007

GC70342

PF-06737007

Also known as 2-[(3R,4S)-3-fluoro-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]piperidin-4-yl]oxy-4-(2-hydroxy-2-methylpropoxy)benzamide

PF-06737007 is a potent pan-Trk inhibitor in cell-based assays withIC50s of 7·7 nM, 15 nM and 3·9 nM for TrkA, TrkB and TrkC, respectively

ChemicalCAS1863905-38-7MW528.49FormulaC25H28F4N2O6
CAS number
1863905-38-7
Molecular weight
528.49
Formula
C25H28F4N2O6
Solubility
DMSO ： ≥ 100 mg/mL (189·22 mM)
InChIKey
AUTGNDRENPBZKA-UXHICEINSA-N
Catalogue number
GC70342
Brand
GLPBIO
Computed properties PubChem CID 118665627 · XLogP 3.6 · TPSA 111 Ų · H-bond donors 2
XLogP
3.6
TPSA
111 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
9
Heavy atoms
37

SMILES CC(C)(COC1=CC(=C(C=C1)C(=O)N)O[C@H]2CCN(C[C@H]2F)C(=O)CC3=CC=C(C=C3)OC(F)(F)F)O

Computed descriptors from PubChem (CID 118665627), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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