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Chemical structure of PF-06751979

GC30876

PF-06751979

Also known as N-[2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(difluoromethoxy)pyridine-2-carboxamide

PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7·3 nM in BACE1 binding assay

ChemicalCAS1818339-66-0MW455.5FormulaC18H19F2N5O3S2
CAS number
1818339-66-0
Molecular weight
455.5
Formula
C18H19F2N5O3S2
Solubility
DMSO ： 150 mg/mL (329·31 mM);Ethanol ： 50 mg/mL (109·77 mM)
InChIKey
ZLZUHACSRMOLLV-RAALSFIWSA-N
Catalogue number
GC30876
Brand
GLPBIO
Computed properties PubChem CID 118435360 · XLogP 2.4 · TPSA 165 Ų · H-bond donors 2
XLogP
2.4
TPSA
165 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
5
Heavy atoms
30

SMILES C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)OC(F)F)N

Computed descriptors from PubChem (CID 118435360), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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