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Chemical structure of MI-389

GC64651

MI-389

Also known as N-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

MI-389 is a PROTAC translation termination factor GSPT1 degrader· MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase

ChemicalCAS2222635-92-7MW654.69FormulaC35H35FN6O6
CAS number
2222635-92-7
Molecular weight
654.69
Formula
C35H35FN6O6
InChIKey
VXBLUAKQWQJPAD-QJOMJCCJSA-N
Catalogue number
GC64651
Brand
GLPBIO
Computed properties PubChem CID 134544040 · XLogP 3.7 · TPSA 170 Ų · H-bond donors 5
XLogP
3.7
TPSA
170 Ų
H-bond donors
5
H-bond acceptors
8
Rotatable bonds
11
Heavy atoms
48

SMILES CC1=C(NC(=C1C(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C3=O)C4CCC(=O)NC4=O)C)/C=C\5/C6=C(C=CC(=C6)F)NC5=O

Computed descriptors from PubChem (CID 134544040), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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