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Chemical structure of MI-3454

GC60246

MI-3454

Also known as N-[3-[[2-cyano-4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]indol-1-yl]methyl]-1-bicyclo[1.1.1]pentanyl]formamide

MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC50 of 0·51 nM· MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis

ChemicalCAS2134169-43-8MW636.73FormulaC32H35F3N8OS
CAS number
2134169-43-8
Molecular weight
636.73
Formula
C32H35F3N8OS
InChIKey
MBFYNGBMAACLAT-UHFFFAOYSA-N
Catalogue number
GC60246
Brand
GLPBIO
Computed properties PubChem CID 130443890 · XLogP 6.1 · TPSA 139 Ų · H-bond donors 3
XLogP
6.1
TPSA
139 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
9
Heavy atoms
45

SMILES CC1=C(C=CC2=C1C=C(N2CC34CC(C3)(C4)NC=O)C#N)CN5CCC(CC5)NC6=C7C=C(SC7=NC(=N6)NC)CC(F)(F)F

Computed descriptors from PubChem (CID 130443890), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.