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Chemical structure of MI-2-2

GC69456

MI-2-2

Also known as 4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine

MI-2-2 is an effective inhibitor of menin-MLL· MI-2-2 binds to menin with low nanomolar affinity (Kd=22 nM) and effectively disrupts the bivalent protein-protein interaction between menin and MLL· MI-2-2 exhibits specific and significant activity in MLL leukemia cells, including inhibition of cell proliferation, downregulation of Hoxa9 expression, and differentiation

ChemicalCAS1454920-20-7MW415.5FormulaC17H20F3N5S2
CAS number
1454920-20-7
Molecular weight
415.5
Formula
C17H20F3N5S2
Solubility
DMSO ： 100 mg/mL (240·67 mM; Need ultrasonic)
InChIKey
SFDROHXKTATJBI-UHFFFAOYSA-N
Catalogue number
GC69456
Brand
GLPBIO
Computed properties PubChem CID 72201086 · XLogP 3.9 · TPSA 98.2 Ų · H-bond donors 0
XLogP
3.9
TPSA
98.2 Ų
H-bond donors
0
H-bond acceptors
9
Rotatable bonds
3
Heavy atoms
27

SMILES CC1(CN=C(S1)N2CCN(CC2)C3=C4C=C(SC4=NC=N3)CC(F)(F)F)C

Computed descriptors from PubChem (CID 72201086), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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