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Chemical structure of EGFR-IN-17

GC64497

EGFR-IN-17

Also known as 5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-5-(1-methylpyrazol-4-yl)-4-morpholin-4-ylphenyl]pyrimidine-2,4-diamine

EGFR-IN-17 is a potent and selective inhibitor of the epidermal growth factor receptor ( IC50 0·0002 μM) to overcome C797S-mediated resistance

ChemicalCAS2817679-31-3MW568.01FormulaC27H31ClN7O3P
CAS number
2817679-31-3
Molecular weight
568.01
Formula
C27H31ClN7O3P
Solubility
DMSO ： 12·5 mg/mL (22·01 mM; ultrasonic and warming and heat to 60°C)
InChIKey
LLUHSVVGRQBIMO-UHFFFAOYSA-N
Catalogue number
GC64497
Brand
GLPBIO
Computed properties PubChem CID 162640600 · XLogP 3.8 · TPSA 106 Ų · H-bond donors 2
XLogP
3.8
TPSA
106 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
39

SMILES CN1C=C(C=N1)C2=CC(=C(C=C2N3CCOCC3)OC)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl

Computed descriptors from PubChem (CID 162640600), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.