Loading...
Chemical structure of JHU395

GC25536

JHU395

Also known as propan-2-yl (2S)-6-diazo-2-[[2,2-dimethylpropanoyloxy(phenyl)methoxy]carbonylamino]-5-oxohexanoate

JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues· JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity

ChemicalCAS2079938-92-2MW447.48FormulaC22H29N3O7
CAS number
2079938-92-2
Molecular weight
447.48
Formula
C22H29N3O7
InChIKey
QQIBFRQTTLIECS-KKFHFHRHSA-N
Catalogue number
GC25536
Brand
GLPBIO
Computed properties PubChem CID 137033613 · XLogP 3.7 · TPSA 110 Ų · H-bond donors 1
XLogP
3.7
TPSA
110 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
14
Heavy atoms
32

SMILES CC(C)OC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)OC(C1=CC=CC=C1)OC(=O)C(C)(C)C

Computed descriptors from PubChem (CID 137033613), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.