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Chemical structure of Lorlatinib

GC14794

Lorlatinib

Also listed as PF-06463922

PF-06463922 (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor· PF-06463922 has Kis of ＜0·025 nM, ＜0·07 nM, and 0·7 nM for ROS1, wild type ALK, and ALKL1196M, respectively· PF-06463922 has anticancer activity

ChemicalCAS1454846-35-5MW406.41FormulaC21H19FN6O2
CAS number
1454846-35-5
Molecular weight
406.41
Formula
C21H19FN6O2
Solubility
≥ 20·3mg/mL in DMSO
InChIKey
IIXWYSCJSQVBQM-LLVKDONJSA-N
Catalogue number
GC14794
Brand
GLPBIO
Computed properties PubChem CID 71731823 · XLogP 1.5 · TPSA 110 Ų · H-bond donors 1
XLogP
1.5
TPSA
110 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
0
Heavy atoms
30

SMILES C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

Computed descriptors from PubChem (CID 71731823), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.