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Chemical structure of PF-06456384 trihydrochloride

GC64506

PF-06456384 trihydrochloride

Also known as 3-cyano-4-[2-[2-[(2-piperidin-4-ylethylamino)methyl]-4-pyridinyl]-4-[3-(trifluoromethyl)phenyl]phenoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide;trihydrochloride

PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively

ChemicalCAS1834610-75-1MW829.18FormulaC35H35Cl3F3N7O3S2
CAS number
1834610-75-1
Molecular weight
829.18
Formula
C35H35Cl3F3N7O3S2
Solubility
DMSO ： 125 mg/mL (150·75 mM; Need ultrasonic)
InChIKey
KUXFHGFSLKUFBC-UHFFFAOYSA-N
Catalogue number
GC64506
Brand
GLPBIO
Computed properties PubChem CID 140810431 · TPSA 179 Ų · H-bond donors 6 · H-bond acceptors 14
TPSA
179 Ų
H-bond donors
6
H-bond acceptors
14
Rotatable bonds
12
Heavy atoms
53

SMILES C1CNCCC1CCNCC2=NC=CC(=C2)C3=C(C=CC(=C3)C4=CC(=CC=C4)C(F)(F)F)OC5=C(C=C(C=C5)S(=O)(=O)NC6=NC=NS6)C#N.Cl.Cl.Cl

Computed descriptors from PubChem (CID 140810431), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.