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Chemical structure of PF-06459988

GC32927

PF-06459988

Also known as 1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-methoxypyrrolidin-1-yl]prop-2-en-1-one

PF-06459988 is an orally activity, irreversible and mutant-selective inhibitor of EGFR mutant forms· PF-06459988 demonstrates high potency and specificity to the T790M-containing double mutant EGFRs· PF-06459988 can be used for the research of cancer

ChemicalCAS1428774-45-1MW431.88FormulaC19H22ClN7O3
CAS number
1428774-45-1
Molecular weight
431.88
Formula
C19H22ClN7O3
Solubility
DMSO ： 50 mg/mL (115·77 mM)
InChIKey
ODMXWZROLKITMS-RISCZKNCSA-N
Catalogue number
GC32927
Brand
GLPBIO
Computed properties PubChem CID 71535003 · XLogP 1.8 · TPSA 110 Ų · H-bond donors 2
XLogP
1.8
TPSA
110 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
30

SMILES CN1C=C(C=N1)NC2=NC3=C(C(=CN3)Cl)C(=N2)OC[C@H]4CN(C[C@@H]4OC)C(=O)C=C

Computed descriptors from PubChem (CID 71535003), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.