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Chemical structure of PF-06648671

GC63407

PF-06648671

Also known as 2-[(1S)-1-[(2S,5R)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione

PF-06648671?is a novel, brain‐penetrable, and orally active γ‐secretase modulator (GSM)

ChemicalCAS1587727-31-8MW538.92FormulaC25H23ClF4N4O3
CAS number
1587727-31-8
Molecular weight
538.92
Formula
C25H23ClF4N4O3
InChIKey
AKCDDYGYIGPEKL-JQOQJDEVSA-N
Catalogue number
GC63407
Brand
GLPBIO
Computed properties PubChem CID 73441910 · XLogP 4.2 · TPSA 67.7 Ų · H-bond donors 0
XLogP
4.2
TPSA
67.7 Ų
H-bond donors
0
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
37

SMILES CC1=CN(C=N1)C2=CC=C3C(=O)N(CCN3C2=O)[C@@H](C)[C@@H]4CC[C@@H](O4)C5=CC(=C(C=C5C(F)(F)F)Cl)F

Computed descriptors from PubChem (CID 73441910), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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