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Chemical structure of PF-06454589

GC64566

PF-06454589

Also known as 4-[5-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively

ChemicalCAS1527473-30-8MW284.32FormulaC14H16N6O
CAS number
1527473-30-8
Molecular weight
284.32
Formula
C14H16N6O
Solubility
DMSO ： 15·62 mg/mL (54·94 mM; ultrasonic and warming and heat to 60°C)
InChIKey
VNWKCLDQBNSJJO-UHFFFAOYSA-N
Catalogue number
GC64566
Brand
GLPBIO
Computed properties PubChem CID 72706837 · XLogP 0.7 · TPSA 71.9 Ų · H-bond donors 1
XLogP
0.7
TPSA
71.9 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
2
Heavy atoms
21

SMILES CN1C=C(C=N1)C2=CNC3=C2C(=NC=N3)N4CCOCC4

Computed descriptors from PubChem (CID 72706837), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.