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Chemical structure of EGFR Inhibitor

GC11312

EGFR Inhibitor

Also known as N-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide

EGFR Inhibitor is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC50of 21 nM· EGFR Inhibitor also inhibits mutant EGFRL858R and EGFRL861Q with IC50s of 63 nM and 4 nM, respectively· EGFR Inhibitor displays strong selectivity for EGFR over HER4 (IC50 = 7640 nM) and a panel of 55 other kinases· EGFR Inhibitor induces cells apoptosis and has antitumor activity

ChemicalCAS879127-07-8MW413.4FormulaC21H18F3N5O
CAS number
879127-07-8
Molecular weight
413.4
Formula
C21H18F3N5O
Solubility
≤0·2mg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide
InChIKey
YOHYSYJDKVYCJI-UHFFFAOYSA-N
Catalogue number
GC11312
Brand
GLPBIO
Computed properties PubChem CID 9549299 · XLogP 4.5 · TPSA 78.9 Ų · H-bond donors 3
XLogP
4.5
TPSA
78.9 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
30

SMILES C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F

Computed descriptors from PubChem (CID 9549299), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.