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Chemical structure of GNE-900

GC73822

GNE-900

Also known as 12-[4-(piperidin-1-ylmethyl)phenyl]-5,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene-4-carbonitrile

GNE-900 is a an ATP-competitive, selective, and orally active ChK1 inhibitor with IC50s of 0·0011, 1·5 µM for ChKl, ChK2, respectively

ChemicalCAS1200126-26-6MW367.45FormulaC23H21N5
CAS number
1200126-26-6
Molecular weight
367.45
Formula
C23H21N5
Solubility
DMSO ： 100 mg/mL (272·15 mM; ultrasonic and warming and heat to 80°C)
InChIKey
PPYHOOZGDDPLKM-UHFFFAOYSA-N
Catalogue number
GC73822
Brand
GLPBIO
Computed properties PubChem CID 44545757 · XLogP 3.9 · TPSA 68.6 Ų · H-bond donors 1
XLogP
3.9
TPSA
68.6 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
28

SMILES C1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC5=C4C=C(N=C5)C#N)N=C3

Computed descriptors from PubChem (CID 44545757), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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