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Chemical structure of GNE-149

GC69182

GNE-149

Also known as (1R,3R)-1-[2,6-difluoro-4-[1-(3-fluoropropyl)azetidin-3-yl]oxyphenyl]-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indole

GNE-149 is an effective and orally active estrogen receptor alpha (ERα; IC50=0·053 nM) antagonist· It is also a selective estrogen receptor degrader (SERD)· GNE-149 can be used for research on breast cancer

ChemicalCAS1953132-75-6MW503.57FormulaC28H33F4N3O
CAS number
1953132-75-6
Molecular weight
503.57
Formula
C28H33F4N3O
Solubility
DMSO ： 50 mg/mL (99·29 mM; ultrasonic and warming and heat to 60°C)
InChIKey
BKHIBYHLBQEIQK-XGCWNURASA-N
Catalogue number
GC69182
Brand
GLPBIO
Computed properties PubChem CID 121410669 · XLogP 5.8 · TPSA 31.5 Ų · H-bond donors 1
XLogP
5.8
TPSA
31.5 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
8
Heavy atoms
36

SMILES C[C@@H]1CC2=C([C@H](N1CC(C)(C)F)C3=C(C=C(C=C3F)OC4CN(C4)CCCF)F)NC5=CC=CC=C25

Computed descriptors from PubChem (CID 121410669), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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