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Chemical structure of GNE-131

GC31065

GNE-131

Also known as N-[7-(1-adamantylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl]cyclopropanesulfonamide

GNE-131 is a potent and selective inhibitor of human sodium channel NaV1·7, with an IC50 of 3 nM

ChemicalCAS1629063-81-5MW442.57FormulaC23H30N4O3S
CAS number
1629063-81-5
Molecular weight
442.57
Formula
C23H30N4O3S
Solubility
DMSO ： 125 mg/mL (282·44 mM)
InChIKey
FPERPEQIXLOVIK-UHFFFAOYSA-N
Catalogue number
GC31065
Brand
GLPBIO
Computed properties PubChem CID 91666633 · XLogP 4.8 · TPSA 94 Ų · H-bond donors 1
XLogP
4.8
TPSA
94 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
31

SMILES C1CC1C2=CN3C(=NN=C3NS(=O)(=O)C4CC4)C=C2OCC56CC7CC(C5)CC(C7)C6

Computed descriptors from PubChem (CID 91666633), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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