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Chemical structure of GNE 220

GC33123

GNE 220

Also known as 6-methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaene

GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM

ChemicalCAS1199590-75-4MW438.53FormulaC25H26N8
CAS number
1199590-75-4
Molecular weight
438.53
Formula
C25H26N8
Solubility
Soluble in DMSO
InChIKey
HXIPOURWZRATPT-UHFFFAOYSA-N
Catalogue number
GC33123
Brand
GLPBIO
Computed properties PubChem CID 58279916 · XLogP 3 · TPSA 78.8 Ų · H-bond donors 1
XLogP
3
TPSA
78.8 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
33

SMILES CC1=C2C(=NC(=N1)C3=CN(N=C3)C)C4=C(N2)N=CC(=C4)C5=CC=C(C=C5)N6CCN(CC6)C

Computed descriptors from PubChem (CID 58279916), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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