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Chemical structure of GNE-207

GC33212

GNE-207

Also known as 5-[8-[5-acetyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]isoquinolin-3-yl]-N-methylpyridine-2-carboxamide

GNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC50 of 1 nM, exhibits a selectively index of?>2500-fold against BRD4 (1)· GNE-207 shows excellent CBP potency, with an EC50 of 18 nM for MYC expression in MV-4-11 cells

ChemicalCAS2158266-58-9MW510.59FormulaC29H30N6O3
CAS number
2158266-58-9
Molecular weight
510.59
Formula
C29H30N6O3
Solubility
DMSO： 200 mg/mL (391·70 mM)
InChIKey
MUJXZEDIWKGKQD-UHFFFAOYSA-N
Catalogue number
GC33212
Brand
GLPBIO
Computed properties PubChem CID 132186469 · XLogP 2 · TPSA 102 Ų · H-bond donors 1
XLogP
2
TPSA
102 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
38

SMILES CC(=O)N1CCC2=C(C1)C(=NN2C3CCOCC3)C4=CC=CC5=CC(=NC=C54)C6=CN=C(C=C6)C(=O)NC

Computed descriptors from PubChem (CID 132186469), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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