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Chemical structure of ARV-393

GC73786

ARV-393

Also known as 2-[6-[[5-chloro-2-[4-[3-[4-[2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]cyclobutyl]oxypiperidin-1-yl]pyrimidin-4-yl]amino]-2-oxo-1-propan-2-ylquinolin-3-yl]oxy-N-methylacetamide

ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6

ChemicalCAS2851885-95-3MW898.42FormulaC46H53ClFN9O7
CAS number
2851885-95-3
Molecular weight
898.42
Formula
C46H53ClFN9O7
Solubility
DMSO ： 11·67 mg/mL (12·99 mM; ultrasonic and warming and heat to 60°C)
InChIKey
ZOGOEUHUEFKKTD-UHFFFAOYSA-N
Catalogue number
GC73786
Brand
GLPBIO
Computed properties PubChem CID 166077922 · XLogP 4.7 · TPSA 179 Ų · H-bond donors 3
XLogP
4.7
TPSA
179 Ų
H-bond donors
3
H-bond acceptors
13
Rotatable bonds
12
Heavy atoms
64

SMILES CC(C)N1C2=C(C=C(C=C2)NC3=NC(=NC=C3Cl)N4CCC(CC4)OC5CC(C5)N6CCC(CC6)C7=C(C8=C(C=C7)C(=O)N(C8)C9CCC(=O)NC9=O)F)C=C(C1=O)OCC(=O)NC

Computed descriptors from PubChem (CID 166077922), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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