Loading...
Chemical structure of ARV-771

GC32685

ARV-771

Also known as (2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

ARV-771 is a potent BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4·7 nM, 8·3 nM, 7·6 nM, 9·6 nM, and 7·6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively

ChemicalCAS1949837-12-0MW986.64FormulaC49H60ClN9O7S2
CAS number
1949837-12-0
Molecular weight
986.64
Formula
C49H60ClN9O7S2
Solubility
DMSO ： ≥ 50 mg/mL (50·68 mM)
InChIKey
PQOGZKGXGLHDGS-QQRWPDCKSA-N
Catalogue number
GC32685
Brand
GLPBIO
Computed properties PubChem CID 126619980 · XLogP 5.9 · TPSA 259 Ų · H-bond donors 4
XLogP
5.9
TPSA
259 Ų
H-bond donors
4
H-bond acceptors
13
Rotatable bonds
19
Heavy atoms
68

SMILES CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCCOCCCOCC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)N[C@@H](C)C5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C

Computed descriptors from PubChem (CID 126619980), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.