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Chemical structure of ARV-471

GC62723

ARV-471

Also known as (3S)-3-[6-[4-[[1-[4-[(1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]phenyl]piperidin-4-yl]methyl]piperazin-1-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

ARV-471 is an orally bioavailable estrogen receptor-targeted (ER-targeted) PROTAC for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer

ChemicalCAS2229711-68-4MW723.9FormulaC45H49N5O4
CAS number
2229711-68-4
Molecular weight
723.9
Formula
C45H49N5O4
Solubility
DMSO ： 110 mg/mL (151·95 mM; Need ultrasonic)
InChIKey
TZZDVPMABRWKIZ-XMOGEVODSA-N
Catalogue number
GC62723
Brand
GLPBIO
Computed properties PubChem CID 134562533 · XLogP 6.4 · TPSA 96.4 Ų · H-bond donors 2
XLogP
6.4
TPSA
96.4 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
54

SMILES C1CC2=C(C=CC(=C2)O)[C@H]([C@H]1C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CC5)CN6CCN(CC6)C7=CC8=C(C=C7)C(=O)N(C8)[C@H]9CCC(=O)NC9=O

Computed descriptors from PubChem (CID 134562533), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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