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Chemical structure of ARV-110

GC62118

ARV-110

Also known as N-[4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindol-5-yl]piperazin-1-yl]methyl]piperidin-1-yl]pyridazine-3-carboxamide

ARV-110 (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader· ARV-110 promotes ubiquitination and degradation of AR· ARV-110 can be used for the research of prostate cancer

ChemicalCAS2222112-77-6MW812.29FormulaC41H43ClFN9O6
CAS number
2222112-77-6
Molecular weight
812.29
Formula
C41H43ClFN9O6
Solubility
DMSO ： 26·67 mg/mL (32·83 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C)
InChIKey
CLCTZVRHDOAUGJ-UHFFFAOYSA-N
Catalogue number
GC62118
Brand
GLPBIO
Computed properties PubChem CID 134414307 · XLogP 3.9 · TPSA 181 Ų · H-bond donors 2
XLogP
3.9
TPSA
181 Ų
H-bond donors
2
H-bond acceptors
13
Rotatable bonds
9
Heavy atoms
58

SMILES C1CC(CCC1NC(=O)C2=NN=C(C=C2)N3CCC(CC3)CN4CCN(CC4)C5=C(C=C6C(=C5)C(=O)N(C6=O)C7CCC(=O)NC7=O)F)OC8=CC(=C(C=C8)C#N)Cl

Computed descriptors from PubChem (CID 134414307), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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