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Chemical structure of GLPG3312

GC73750

GLPG3312

Also known as N-cyclopropyl-2-(difluoromethoxy)-6-methoxy-4-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]benzamide

GLPG3312 (Compound 28) is a selective pan-SIK inhibitor with IC50 values of 2·0 nM, 0·7 nM and 0·6 nM for SIK1, SIK2 and SIK3, respectively

ChemicalCAS2340388-72-7MW453.44FormulaC23H21F2N5O3
CAS number
2340388-72-7
Molecular weight
453.44
Formula
C23H21F2N5O3
Solubility
DMSO ： 100 mg/mL (220·54 mM; Need ultrasonic)
InChIKey
PFTXFNSHFZLJNT-UHFFFAOYSA-N
Catalogue number
GC73750
Brand
GLPBIO
Computed properties PubChem CID 151447433 · XLogP 3.8 · TPSA 83.2 Ų · H-bond donors 1
XLogP
3.8
TPSA
83.2 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
33

SMILES CN1C=C(C=N1)C2=CC3=C(C=C2)N(C=N3)C4=CC(=C(C(=C4)OC(F)F)C(=O)NC5CC5)OC

Computed descriptors from PubChem (CID 151447433), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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