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Chemical structure of EGFR T790M/L858R-IN-2

GC73274

EGFR T790M/L858R-IN-2

Also known as N-[3-[[6-fluoro-2-[4-(4-methylpiperazin-1-yl)anilino]quinazolin-4-yl]amino]phenyl]prop-2-enamide

EGFR T790M/L858R-IN-2 is a potent and selective EGFRT790M/L858R inhibitor with IC50 values of 3·5, 1290 nM for EGFRT790M/L858R, EGFR WT, respectively

ChemicalCAS2955607-40-4MW497.57FormulaC28H28FN7O
CAS number
2955607-40-4
Molecular weight
497.57
Formula
C28H28FN7O
Solubility
DMSO ： 100 mg/mL (200·98 mM; Need ultrasonic)
InChIKey
KDWNVZXLHSMELQ-UHFFFAOYSA-N
Catalogue number
GC73274
Brand
GLPBIO
Computed properties PubChem CID 168264808 · XLogP 5.1 · TPSA 85.4 Ų · H-bond donors 3
XLogP
5.1
TPSA
85.4 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
37

SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C=C(C=C4)F)C(=N3)NC5=CC(=CC=C5)NC(=O)C=C

Computed descriptors from PubChem (CID 168264808), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.