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Chemical structure of AMG-1694

GC70590

AMG-1694

Also known as (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-ol

AMG-1694 is a potent glucokinase-glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity

ChemicalCAS1361217-07-3MW533.63FormulaC23H30F3N3O4S2
CAS number
1361217-07-3
Molecular weight
533.63
Formula
C23H30F3N3O4S2
InChIKey
OJTJLEFGCNYTBQ-RBDMOPTHSA-N
Catalogue number
GC70590
Brand
GLPBIO
Computed properties PubChem CID 66582747 · XLogP 3.3 · TPSA 110 Ų · H-bond donors 1
XLogP
3.3
TPSA
110 Ų
H-bond donors
1
H-bond acceptors
11
Rotatable bonds
6
Heavy atoms
35

SMILES C[C@H]1COCCN1C[C@H]2CN(CCN2C3=CC=C(C=C3)[C@](C)(C(F)(F)F)O)S(=O)(=O)C4=CC=CS4

Computed descriptors from PubChem (CID 66582747), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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