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Chemical structure of AMG 333

GC65611

AMG 333

Also known as 6-[[(S)-(3-fluoro-2-pyridinyl)-[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]carbamoyl]pyridine-3-carboxylic acid

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM

ChemicalCAS1416799-28-4MW453.32FormulaC20H12F5N3O4
CAS number
1416799-28-4
Molecular weight
453.32
Formula
C20H12F5N3O4
Solubility
DMSO ： ≥ 125 mg/mL (275·74 mM)
InChIKey
QEBYISWYMFIXOZ-INIZCTEOSA-N
Catalogue number
GC65611
Brand
GLPBIO
Computed properties PubChem CID 71144018 · XLogP 3.5 · TPSA 101 Ų · H-bond donors 2
XLogP
3.5
TPSA
101 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
6
Heavy atoms
32

SMILES C1=CC(=C(N=C1)[C@H](C2=CC(=C(C=C2)OC(F)(F)F)F)NC(=O)C3=NC=C(C=C3)C(=O)O)F

Computed descriptors from PubChem (CID 71144018), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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