GC39695
AMG 511
Also known as 4-[2-[(5-fluoro-6-methoxy-3-pyridinyl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]-3-pyridinyl]-6-methyl-1,3,5-triazin-2-amine
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively· AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease· AMG 511 exhibits anti-tumor activity in mouse glioblastoma xenograft model
ChemicalCAS1253573-53-3MW517.58FormulaC22H28FN9O3S
- CAS number
- 1253573-53-3
- Molecular weight
- 517.58
- Formula
- C22H28FN9O3S
- Solubility
- Soluble in DMSO
- InChIKey
- KUGIFHQBIIHRIZ-CYBMUJFWSA-N
- Catalogue number
- GC39695
- Brand
- GLPBIO
Computed properties PubChem CID 56947516 · XLogP 1.1 · TPSA 161 Ų · H-bond donors 2
- XLogP
- 1.1
- TPSA
- 161 Ų
- H-bond donors
- 2
- H-bond acceptors
- 13
- Rotatable bonds
- 7
- Heavy atoms
- 36
SMILES CC1=NC(=NC(=N1)N)C2=C(N=CC(=C2)[C@@H](C)N3CCN(CC3)S(=O)(=O)C)NC4=CC(=C(N=C4)OC)F
Computed descriptors from PubChem (CID 56947516), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il