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Chemical structure of AMG 837

GC19030

AMG 837

Also known as (3S)-3-[4-[[3-[4-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]hex-4-ynoic acid

AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents

ChemicalCAS865231-46-5MW438.44FormulaC26H21F3O3
CAS number
865231-46-5
Molecular weight
438.44
Formula
C26H21F3O3
Solubility
DMSO ： ≥ 42 mg/mL (92·22 mM)
InChIKey
ZOPNBMMVVZRSGH-NRFANRHFSA-N
Catalogue number
GC19030
Brand
GLPBIO
Computed properties PubChem CID 46854655 · XLogP 6.2 · TPSA 46.5 Ų · H-bond donors 1
XLogP
6.2
TPSA
46.5 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
32

SMILES CC#C[C@@H](CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)C3=CC=C(C=C3)C(F)(F)F

Computed descriptors from PubChem (CID 46854655), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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