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Chemical structure of GNE-8505

GC70391

GNE-8505

Also known as 5-[1-(cyclopropylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine

GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK)

ChemicalCAS1620573-48-9MW419.44FormulaC21H24F3N5O
CAS number
1620573-48-9
Molecular weight
419.44
Formula
C21H24F3N5O
Solubility
DMSO ： 100 mg/mL (238·41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
IRPVABHDSJVBNZ-RTHVDDQRSA-N
Catalogue number
GC70391
Brand
GLPBIO
Computed properties PubChem CID 90292687 · XLogP 1.9 · TPSA 69.2 Ų · H-bond donors 1
XLogP
1.9
TPSA
69.2 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
30

SMILES C1CC1CN2C(=CC(=N2)C3=CC(=C(N=C3)N)C(F)(F)F)C4[C@H]5[C@@H]4CN(C5)C6COC6

Computed descriptors from PubChem (CID 90292687), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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