GC68760
BI-2865
Also known as (4S)-2-amino-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile
BI-2865 is a non-covalent pan-KRAS inhibitor· BI-2865 binds to KRAS WT, G12C, G12D, G12V and G13D mutants with KD values of 6·9, 4·5, 32, 26 and 4·3 nM respectively· BI-2865 inhibits the proliferation of BaF3 cells expressing KRAS G12C, G12D or G12V mutations (average IC50: approximately 140 nM)
ChemicalCAS2937327-93-8MW465.57FormulaC23H27N7O2S
- CAS number
- 2937327-93-8
- Molecular weight
- 465.57
- Formula
- C23H27N7O2S
- InChIKey
- MIUFORKWYHBPRW-HMFCALDFSA-N
- Catalogue number
- GC68760
- Brand
- GLPBIO
Computed properties PubChem CID 168268166 · XLogP 4.1 · TPSA 155 Ų · H-bond donors 1
- XLogP
- 4.1
- TPSA
- 155 Ų
- H-bond donors
- 1
- H-bond acceptors
- 10
- Rotatable bonds
- 5
- Heavy atoms
- 33
SMILES C[C@@H]([C@@H]1CCCN1C)OC2=NC(=NC=C2)C3=NOC(=N3)[C@]4(CCCC5=C4C(=C(S5)N)C#N)C
Computed descriptors from PubChem (CID 168268166), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il