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Chemical structure of BI-3663

GC65457

BI-3663

Also known as N-[2-[2-[2-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxy-4-[[4-[(3-oxo-1,2-dihydroinden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation· BI-3663 inhibits PTK2 with an IC50 of 18 nM· BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker· Anti-cancer activity

ChemicalCAS2341740-84-7MW917.84FormulaC44H42F3N7O12
CAS number
2341740-84-7
Molecular weight
917.84
Formula
C44H42F3N7O12
Solubility
DMSO ： 300 mg/mL (326·85 mM; Need ultrasonic)
InChIKey
ADTXLFJKQHYGPM-UHFFFAOYSA-N
Catalogue number
GC65457
Brand
GLPBIO
Computed properties PubChem CID 137628657 · XLogP 2.9 · TPSA 243 Ų · H-bond donors 4
XLogP
2.9
TPSA
243 Ų
H-bond donors
4
H-bond acceptors
18
Rotatable bonds
20
Heavy atoms
66

SMILES COC1=C(C=CC(=C1)C(=O)NCCOCCOCCOCCC(=O)NC2=CC=CC3=C2C(=O)N(C3=O)C4CCC(=O)NC4=O)NC5=NC=C(C(=N5)OC6=CC=CC7=C6C(=O)CC7)C(F)(F)F

Computed descriptors from PubChem (CID 137628657), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.