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Chemical structure of BI-2545

GC60074

BI-2545

Also known as [3,5-bis(trifluoromethyl)phenyl]methyl (1S,5R)-6-[(2H-benzotriazole-5-carbonylamino)methyl]-3-azabicyclo[3.1.0]hexane-3-carboxylate

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC50s of 2·2 nM and 3·4 nM for human ATX and rat ATX, respectively

ChemicalCAS2162961-71-7MW527.42FormulaC23H19F6N5O3
CAS number
2162961-71-7
Molecular weight
527.42
Formula
C23H19F6N5O3
Solubility
DMSO： 250 mg/mL (474·01 mM)
InChIKey
ZDOBSAPHUUUOHX-ALOPSCKCSA-N
Catalogue number
GC60074
Brand
GLPBIO
Computed properties PubChem CID 131953432 · XLogP 3.8 · TPSA 100 Ų · H-bond donors 2
XLogP
3.8
TPSA
100 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
6
Heavy atoms
37

SMILES C1[C@@H]2[C@@H](C2CNC(=O)C3=CC4=NNN=C4C=C3)CN1C(=O)OCC5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F

Computed descriptors from PubChem (CID 131953432), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.