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Chemical structure of GNE-274

GC65606

GNE-274

Also known as (2S)-3-(3-hydroxyphenyl)-4-methyl-2-[4-[(1-propylazetidin-3-yl)methoxy]phenyl]-2H-chromen-6-ol

GNE-274 is a non-degrader that is structurally related to GDC-0927 (ER degrader)· GNE-274 does not induce ER turnover and functions as a partial ER agonist in breast cancer cell lines·?GNE-274 increase chromatin accessibility at ER-DNA binding sites, while GDC-0927 do not· GNE-274 is a potent inhibitor of ER-ligand binding domain (LBD)· GNE-274 can be used for cancer research

ChemicalCAS2369048-69-9MW457.56FormulaC29H31NO4
CAS number
2369048-69-9
Molecular weight
457.56
Formula
C29H31NO4
InChIKey
ABSGIUXAPWSTBC-LJAQVGFWSA-N
Catalogue number
GC65606
Brand
GLPBIO
Computed properties PubChem CID 162641011 · XLogP 5.3 · TPSA 62.2 Ų · H-bond donors 2
XLogP
5.3
TPSA
62.2 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
7
Heavy atoms
34

SMILES CCCN1CC(C1)COC2=CC=C(C=C2)[C@H]3C(=C(C4=C(O3)C=CC(=C4)O)C)C5=CC(=CC=C5)O

Computed descriptors from PubChem (CID 162641011), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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