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Chemical structure of JI051

GC34635

JI051

Also known as (E)-N-[2-(2-ethoxyphenyl)ethyl]-3-(7-methoxy-1H-indol-3-yl)prop-2-enamide

JI051 is a stabilizer for the Hes1-PHB2 interaction· JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1· Anti-cancer activity

ChemicalCAS2234281-75-3MW364.44FormulaC22H24N2O3
CAS number
2234281-75-3
Molecular weight
364.44
Formula
C22H24N2O3
Solubility
DMSO ： 125 mg/mL (342·99 mM)
InChIKey
CQZPBIZGVIRKOC-VAWYXSNFSA-N
Catalogue number
GC34635
Brand
GLPBIO
Computed properties PubChem CID 138319697 · XLogP 4 · TPSA 63.4 Ų · H-bond donors 2
XLogP
4
TPSA
63.4 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
8
Heavy atoms
27

SMILES CCOC1=CC=CC=C1CCNC(=O)/C=C/C2=CNC3=C2C=CC=C3OC

Computed descriptors from PubChem (CID 138319697), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.