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Chemical structure of GNE-375

GC65326

GNE-375

Also known as 6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-4-carbonyl)phenyl]-2-methyl-1H-pyrrolo[2,3-c]pyridin-7-one

GNE-375 is a potent and highly selective BRD9 inhibitor with an IC50 of 5 nM· GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2· GNE-375 decreases BRD9 binding to chromatin

ChemicalCAS1926989-06-1MW451.51FormulaC25H29N3O5
CAS number
1926989-06-1
Molecular weight
451.51
Formula
C25H29N3O5
Solubility
DMSO ： 50 mg/mL (110·74 mM; Need ultrasonic)
InChIKey
FWTDDBIMDSVPTR-AATRIKPKSA-N
Catalogue number
GC65326
Brand
GLPBIO
Computed properties PubChem CID 121342417 · XLogP 2.1 · TPSA 84.1 Ų · H-bond donors 1
XLogP
2.1
TPSA
84.1 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
33

SMILES C/C=C/CN1C=C(C2=C(C1=O)NC(=C2)C)C3=CC(=C(C=C3OC)C(=O)N4CCOCC4)OC

Computed descriptors from PubChem (CID 121342417), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.