GC25727
PF-06446846
Also known as N-(3-chloro-2-pyridinyl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide
PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor· PF-06446846 selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region
ChemicalCAS1632250-49-7MW433.89FormulaC22H20ClN7O
- CAS number
- 1632250-49-7
- Molecular weight
- 433.89
- Formula
- C22H20ClN7O
- Solubility
- DMSO： 87 mg/mL (200·51 mM);Water： Insoluble;Ethanol： 87 mg/mL (200·51 mM)
- InChIKey
- FDTXHWQFIXYHCL-QGZVFWFLSA-N
- Catalogue number
- GC25727
- Brand
- GLPBIO
Computed properties PubChem CID 86271238 · XLogP 3.1 · TPSA 88.8 Ų · H-bond donors 1
- XLogP
- 3.1
- TPSA
- 88.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 31
SMILES C1C[C@H](CNC1)N(C2=C(C=CC=N2)Cl)C(=O)C3=CC=C(C=C3)N4C5=C(C=CC=N5)N=N4
Computed descriptors from PubChem (CID 86271238), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il