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Chemical structure of RMC-4630

GC63487

RMC-4630

Also known as [6-[(2-amino-3-chloro-4-pyridinyl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl]methanol

RMC-4630 (SHP2-IN-7) is an SHP2 inhibitor extracted from patent WO2018013597

ChemicalCAS2172652-48-9MW450.99FormulaC20H27ClN6O2S
CAS number
2172652-48-9
Molecular weight
450.99
Formula
C20H27ClN6O2S
Solubility
DMSO ： 50 mg/mL (110·87 mM; ultrasonic and warming and heat to 60°C)
InChIKey
HISJAYUQVHMWTA-BLLLJJGKSA-N
Catalogue number
GC63487
Brand
GLPBIO
Computed properties PubChem CID 134182831 · XLogP 1.2 · TPSA 149 Ų · H-bond donors 3
XLogP
1.2
TPSA
149 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
4
Heavy atoms
30

SMILES C[C@H]1[C@H](C2(CCN(CC2)C3=NC(=C(N=C3CO)SC4=C(C(=NC=C4)N)Cl)C)CO1)N

Computed descriptors from PubChem (CID 134182831), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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