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Chemical structure of RMC-0331

GC62494

RMC-0331

Also known as [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl]-(4-methoxyoxan-4-yl)methanone

RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor· RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction

ChemicalCAS2488788-52-7MW499.91FormulaC22H25ClF3N5O3
CAS number
2488788-52-7
Molecular weight
499.91
Formula
C22H25ClF3N5O3
Solubility
DMSO ： 125 mg/mL (250·05 mM; Need ultrasonic)
InChIKey
HOBOGRTXXDLZIB-GFCCVEGCSA-N
Catalogue number
GC62494
Brand
GLPBIO
Computed properties PubChem CID 155687064 · XLogP 2.6 · TPSA 103 Ų · H-bond donors 2
XLogP
2.6
TPSA
103 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
5
Heavy atoms
34

SMILES C[C@H](C1=CC(=CC(=C1)N)C(F)(F)F)NC2=NC(=NC3=C2CN(C3)C(=O)C4(CCOCC4)OC)Cl

Computed descriptors from PubChem (CID 155687064), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.