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Chemical structure of RMC-5552

GC62649

RMC-5552

Also known as [(1R,2R,4S)-2-methoxy-4-[(2R)-2-[(1R,9S,12S,14R,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,14,18-trihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,20-tetraoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]cyclohexyl] N-[2-[2-[2-[2-[2-[2-[2-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate

RMC-5552 is a potent and selective inhibitor of mTORC1· RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0·14 nM and 0·48 nM, respectively· RMC-5552 has anti-cancer activity

ChemicalCAS2382768-62-7MW1778.13FormulaC93H136N10O24
CAS number
2382768-62-7
Molecular weight
1778.13
Formula
C93H136N10O24
Solubility
DMSO ： 166·67 mg/mL (93·73 mM; Need ultrasonic)
InChIKey
IUTYTXDIGUNPAA-GKVGALOGSA-N
Catalogue number
GC62649
Brand
GLPBIO
Computed properties PubChem CID 162640850 · XLogP 7 · TPSA 433 Ų · H-bond donors 6
XLogP
7
TPSA
433 Ų
H-bond donors
6
H-bond acceptors
30
Rotatable bonds
38
Heavy atoms
127

SMILES C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H]([C@@H](C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)N5CCC6=C(C5)C=CC(=C6)CN7C8=NC=NC(=C8C(=N7)C9=CC1=C(C=C9)OC(=N1)N)N)O)C)/C)O)OC)C)C)/C)OC

Computed descriptors from PubChem (CID 162640850), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.