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Chemical structure of PF-06426779

GC61176

PF-06426779

Also known as 1-[[(2S,3S,4S)-4-fluoro-3-methyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide

PF-06426779 is a potent and selective inhibitor of interleukin?1 receptor associated kinase 4 (IRAK4), with an IC50 of 0·3 nM

ChemicalCAS1817628-40-2MW347.34FormulaC17H18FN3O4
CAS number
1817628-40-2
Molecular weight
347.34
Formula
C17H18FN3O4
Solubility
DMSO： 250 mg/mL (719·76 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
GISRWBROCYNDME-PELMWDNLSA-N
Catalogue number
GC61176
Brand
GLPBIO
Computed properties PubChem CID 118414536 · XLogP 1.6 · TPSA 104 Ų · H-bond donors 2
XLogP
1.6
TPSA
104 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
25

SMILES C[C@H]1[C@H](NC(=O)[C@H]1F)COC2=NC=CC3=CC(=C(C=C32)OC)C(=O)N

Computed descriptors from PubChem (CID 118414536), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.